Table 4.

Number of differentially expressed genes (DEGs) for (A) GNP treatments vs. unexposed controls (C) in wildtype, ASC-deficient, and NLRP3-deficient THP-1-derived cells, and (B) unexposed wildtype vs. ASC-deficient and NLRP3-deficient THP-1-derived cells. p < 0.001. False discovery rate (FDR) = 11%. The total number of DEGs in panel A is 103 since, from the 40 DEGs for NLRP3-def, one overlaps with GNP-4 nanospheres vs. C (wildtype) and one with GNP-6 nanorods vs. C (ASC-def).

Comparison	Cells	# of DEGs
A
GNP-1 nanostars vs. C	Wild-type	6
GNP-4 nanospheres vs. C	Wild-type	9
GNP-6 nanorods vs. C	Wild-type	15
GNP-6 nanorods vs. C	ASC-def	35
GNP-6 nanorods vs. C	NLRP3-def	40
B
Wildtype C vs. ASC-def C		332
Wildtype C vs. NLRP3-def C		219