Figure 6.
Light-induced cytotoxicity of Ag-PEG-HER2 nanoparticles in vitro. (a): Viability of SKOV3-1ip cells (%) depending on the concentration of targeted silver NPs in the medium (μg/mL) (shown in different colors) and the irradiation mode (with/without light) obtained with the MTT test. (b): ROS generation upon the blue light irradiation of cells labeled with affibody-decorated Ag NPs: dependence of the fluorescence intensity (r.u.·103) of cells labeled with ROS indicator on the concentration of nanoparticles and irradiation time. (c): Colony formation assay showing the cytotoxic activity of combination affibody-modified Ag-PEG-HER2 particles and irradiation with the blue LED matrix at a power of 95 mW/cm2 for HER2-positive cells.