Figure 2.

Molecular mechanisms triggering cytokine activation in response to adenovirus infection. Several main events trigger cytokine and chemokine activation during adenovirus infection. The hubs that play the major roles are shown in red. The orange molecules are associated with IRF3-dependent transcription. The teal color indicates the factors that signal through the NF-κB transcription hub. Integrin β3 activation of IL-1α and IL-1α-dependent augmentation of cytokine production are other main events leading to cytokine expression after adenovirus infection. The data for individual proteins, reported in references from [30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105,106,107,108,109,110,111,112,113,114,115,116], are shown with superscript numbers.