Table 2.
Clinical manifestation of COVID-19 in the entire population and in successive waves of the pandemic.
| Symptom | Second Wave (n = 1069) |
Third Wave (n = 782) |
Fourth Wave (n = 110) |
p * | The Whole Group (n = 1961) |
|
|---|---|---|---|---|---|---|
| Patient with clinical symptoms | 1060 (99.2) | 779 (99.6) | 110 (100.0) | 0.320 | 1949 (99.4) | |
| Temperature < 36.6 °C | 166 (15.5) | 128 (16.4) | 14 (12.8) | 0.599 | 308 (15.7) | |
| Temperature 36.6–37.5 °C | 249 (23.3) | 162 (20.7) | 26 (23.6) | 0.551 | 437 (22.3) | |
| Temperature > 37.5 °C | 554 (51.8) | 439 (56.1) | 61 (55.5) | 0.172 | 1054 (53.7) | |
| Cough | 653 (61.1) | 541 (69.2) | 87 (79.0) | <0.001 | 1281 (65.3) | |
| Dyspnoea | 499 (46.7) | 433 (55.4) | 48 (43.6) | <0.001 | 980 (49.9) | |
| Rhinitis | 310 (29.0) | 276 (35.3) | 58 (52.7) | <0.001 | 644 (32.8) | |
| Isolated olfactory dysfunction | 118 (11.0) | 50 (6.4) | 16 (14.6) | <0.001 | 184 (9.4) | |
| Isolated taste dysfunction | 57 (5.3) | 48 (6.1) | 8 (7.3) | 0.598 | 113 (5.8) | |
| Taste and olfactory dysfunction | 544 (50.9) | 283 (36.2) | 61 (55.5) | <0.001 | 888 (45.3) | |
| Taste and/or olfactory dysfunction | 679 (63.5) | 349 (44.6) | 27 (24.6) | <0.001 | 1055 (53.8) | |
| Weakness | 793 (74.2) | 625 (79.9) | 84 (76.4) | 0.015 | 1502 (76.6) | |
| Chest pain | 465 (43.5) | 393 (50.3) | 50 (45.5) | 0.016 | 908 (46.3) | |
| Back pain | 594 (55.6) | 433 (55.4) | 53 (48.2) | 0.326 | 1080 (55.1) | |
| Leg pain | 484 (45.3) | 374 (47.8) | 48 (43.6) | 0.474 | 906 (46.2) | |
| Headache | 614 (57.4) | 458 (58.6) | 61 (55.5) | 0.781 | 1138 (57.8) | |
| Arthralgia | 449 (42.0) | 375 (48.0) | 44 (40.0) | 0.025 | 868 (44.3) | |
| Diarrhoea | 222 (20.8) | 171 (21.9) | 23 (20.9) | 0.845 | 416 (21.2) | |
| Vomits | 66 (6.2) | 64 (8.2) | 8 (7.3) | 0.247 | 138 (7.0) | |
| Chills | 399 (37.3) | 316 (40.4) | 45 (40.9) | 0.361 | 760 (38.8) | |
| Labile blood pressure values | 150 (14.0) | 138 (17.7) | 20 (18.2) | 0.082 | 308 (15.7) | |
| Hearing dysfunction | 92 (8.6) | 103 (13.2) | 16 (14.6) | 0.003 | 211 (10.8) | |
| Average number of symptoms | 8.11 ± 3.7 | 8.4 ± 3.4 | 8.32 ± 3.2 | 0.973 ** | 8.22 ± 3.6 | |
| Duration of symptoms [days] | 10.3 ± 9.9 | 10.8 ± 8.1 | 12.2 ± 8.5 | 0.298 ** | 10.6 ± 9.4 | |
| Subjective assessment of the severity of the disease | 0 | 105 (9.8) | 64 (8.2) | 0 (0.0) | <0.001 | 169 (8.6) |
| 1 | 340 (31.8) | 176 (22.5) | 33 (30.0) | 549 (28.0) | ||
| 2 | 281 (26.3) | 215 (27.5) | 35 (31.8) | 531 (27.1) | ||
| 3 | 343 (32.1) | 327 (41.8) | 42 (38.2) | 712 (36.3) | ||
| M SD | 1.81 ± 0.9 | 2.03 ± 0.9 | 2.08 ± 0.8 | <0.001 ** | 1.9 ± 0.9 | |
* Chi-squared test. ** Mann–Whitney U Test. Statistically significant values are in bold with the significance level set at p < 0.05.