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. 2022 May 21;23(10):5792. doi: 10.3390/ijms23105792

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Distribution of the 12-SNP weighted polygenic risk score (wPRS) within the deciles of the Whitehall II control cohort [7]. Comparison between dyslipidemic (DLP = ADH/FCHL), ADH, or FCHL probands carrying an APOE rare variant or without any ADH/FCHL causative mutation (/M-). Green arrows indicate the percentage of probands with a low wPRS and a probability of monogenic DLP that gradually increases under decile V. Red arrows indicate the percentage of probands with a wPRS in the top three deciles with a high probability of polygenic DLP.