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. 2022 May 21;23(10):5792. doi: 10.3390/ijms23105792

Figure 5.

Figure 5

Multiple of median for LDL-C (LDL-MoM) and weighted polygenic risk score (wPRS) among carriers of different variants. (A) LDL-MoM in carriers of 5’UTR, 3’UTR, missense, synonymous, and deletion variants for the whole cohort. (B) LDL-MoM in carriers of exonic variants for the whole cohort. a Other exonic variants than the five shown in the graph because with at least three carriers, b All exonic substitutions. (C) wPRS in carriers of p.Leu167del, p.Leu46Pro/E4, and other variants for the whole cohort. (D) wPRS in the carriers of p.Leu167del, p.Leu46Pro/E4, and other variants in the ADH cohort. c Variants other than p.Leu46Pro-E4 and p.Leu167del (exonic, intronic, 5’ and 3’ UTR). * p < 0.05, ** p < 0.005, non-parametric Mann–Whitney test.