Scheme 4.
Synthesis of 2-(5-arylidene-2,4-dioxothiazolidin-3-yl)acetic acid derivatives. Reagents and conditions: (v) DMF, K2CO3, 80 °C; (vi) CH3COOH/HCl reflux; (vii) CF3COOH/CH2Cl2, r.t.; (ii) AcOH, MeNH2, reflux; (iii) EtOH, piperidine, reflux.
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