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. 2022 May 1;15(5):563. doi: 10.3390/ph15050563

Scheme 5.

Scheme 5

Synthesis of 2-(2-thioxo-5-arylidene-4-oxothiazolidin-3-yl)acetic acid derivatives. Reagents and conditions: (v) DMF, K2CO3, 80 °C; (ii) AcOH, MeNH2, reflux; (vii) CF3COOH/CH2Cl2, r.t.