Table 3.
Antifungal activity of synthesized compounds (MIC in mg/L). Experiments were performed at least 3 times.
| ||||||||
|---|---|---|---|---|---|---|---|---|
| R1 | R2 |
C. albicans ATCC 24433 24h 48h |
A. niger 37a | A. fumigatus ATCC 46645 | M. canis B-200 |
T. rubrum 2002 |
||
| 4a | 4-Cl | H | >128 | >128 | 64 | >64 | 16 | 32 |
| 4b | 3,4-(OBn)2 | H | >128 | >128 | >64 | >64 | >32 | >32 |
| 4c | 2,4-di-Cl | H | >128 | >128 | 64 | >64 | 64 | 128 |
| 4d | 2-OH-5-Cl | H | 64 | 64 | 16 | 32 | 64 | 16 |
| 4e | 2-OH-3,5-di-Cl | H | 8 | 32 | 16 | 32 | 32 | 16 |
| 15b | 3,4-(OBn)2 | H | 32 | >64 | >64 | >64 | >64 | >64 |
| 5a | 4-Cl | COOEt | 8–16 | 16 | 1 | 4 | 8 | 8 |
| 5b | 4-Cl | COOi-Bu | 4 | 8 | 8–16 | 16 | 4–8 | 8 |
| 5c | 4-Cl | COOAll | 8 | 8 | 8 | 16 | 8 | 4 |
| 5d | 4-Cl | COOPh | 16 | 64 | 32 | 64 | 4 | 32 |
| 5e | 4-Cl | COOBn | >64 | >64 | 64 | >64 | 16 | 32 |
| 7a | 4-Cl | COPh | 8 | 32 | 32 | 64 | 4 | 8–16 |
| 7b | 3,4-(OBn)2 | COPh | >128 | >125 | 32 | >64 | >64 | >64 |
| 10a | 4-Cl | CH2COOt-Bu | 32–64 | 64 | >64 | >64 | >64 | >64 |
| 10b | 3,4-(OBn)2 | CH2COOt-Bu | >32 | >64 | >64 | >64 | >64 | >64 |
| 11a | 4-Cl | CH2COOEt | 32–64 | >64 | >64 | >64 | >64 | >64 |
| 11b | 3,4-(OBn)2 | CH2COOEt | >64 | >64 | >64 | >64 | >64 | >64 |
| 12a | 4-Cl | CH2COOH | 32 | >64 | 64 | >64 | 32–64 | 32 |
| 12b | 3,4-(OBn)2 | CH2COOH | 64 | >64 | >64 | >64 | >64 | >64 |
| 12c | 2,4-Cl2 | CH2COOH | 32 | >32 | 16 | 2 | 16–32 | 32 |
| 12d | 2-OH-5-Cl | CH2COOH | 32 | >64 | 4–8 | 16 | 16 | 16 |
| 12e | 2-OH-3,5-di-Cl | CH2COOH | 0.125 | 0.5 | 8 | 16 | 16 | 16 |
| 17b | 3,4-(OBn)2 | CH2COOH | 64 | >64 | >64 | >64 | >64 | >64 |
| 17e | 2-OH-3,5-di-Cl | CH2COOH | 8 | 16 | 8 | 16 | 2 | 8 |
| Mycosidine (R1 = 4-Cl, R2 = COOMe) | 16 | 32 | 4 | 8 | 4 | 4 | ||
| Fluconazole | 4 | 32 | >64 | >64 | 16 | 64 | ||