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. 2022 May 16;23(10):5533. doi: 10.3390/ijms23105533

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of PXS-5505 treatment on collagen content and crosslinks of elastin and collagen in bleomycin-induced fibrotic mouse lung. Bleomycin elevated the expression of (A) hydroxyproline (HYP), (B) elastin crosslinks [desmosine (Des) and isodesmosine (Isodes)] and (C) immature [dihydroxy-lysinonorleucine (DHLNL) and hydroxylysinonorleucine (HLNL)] and mature [pyridinoline (PYD) and deoxypyridinoline (DPD)] collagen crosslinks in the mouse lungs; PXS-5505 treatment reduced these crosslinking markers induced by bleomycin. Levels were measured using LC-MS/MS methodologies (* p < 0.05, ** p < 0.01, *** p < 0.001 between the indicated groups).