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. 2022 May 20;23(10):5705. doi: 10.3390/ijms23105705

Figure 2.

Figure 2

Expression of TSP-1 contributes to leukocyte adhesion to retinal vessels during LPS-induced acute uveitis inflammation in mice. Acute uveitis was induced in WT or TSP-1-deficient mice by administering 150 mg of LPS i.p. After 24 h, firmly adherent leukocytes in retinal vessels were visualized by perfusing the mice with rhodamine-conjugated ConA (red) before harvesting the retinas. (a) Representative images of retina whole mounts from untreated WT mice as normal and WT and TSP-1-deficient mice with EIU are marked with white arrows to indicate adherent leukocytes; (b) Quantitative assessment of adherent leukocytes in retinal vessels (n = 3–4 each group). Data are expressed as leukocyte adhesion relative to mean number of adherent leukocytes in WT retina ± SEM. * p < 0.05. Scale bar = 200 µM.