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Schematic representation of the involvement of TSP-1 and its receptors, CD47 and CD36, in regulating VCAM-1 expression in vascular endothelial cells exposed to TNF-α vs. IL-17. Predominant signaling via CD36 drives increased VCAM-1 expression mediated by endogenous TSP-1, which is increased in response to TNF-α. However, IL-17 exposure of cells reduces their endogenous TSP-1 expression, allowing the dominance of inhibitory CD47 signaling that downregulates VCAM-1 expression.
