Figure 1.

Metabolic targets of nutrients and nutraceuticals in TNBC cells. Akt, protein kinase B; AS, Antrodia Salmonea, BITC, benzyl isothiocyanate; D₃, vitamin D₃ (calcitriol); Delta T₃, vitamin E delta-tocotrienol; DHA, docosahexaenoic acid; DHAP, dihydroxyacetone phosphate; EGCG, epigallocatechin gallate; GA3P, glyceraldehyde-3-phosphate; GLUT, glucose transporter; HIF-1a, hypoxia inducible factor 1 alpha; ISL, isoliquiritigenin; LDHA, lactate dehydrogenase A; MPC, mitochondrial pyruvate carrier; mTOR, mammalian target of rapamycin; mTORC1, mammalian target of rapamycin complex 1; OAA, oxaloacetate; PI3K, phosphoinositide 3-kinase; PIP₃, phosphatidylinositol (3,4,5)-trisphosphate; ROS, reactive oxygen species; SucCoA, succinyl-coenzyme A; TSC1/II, Tuberous sclerosis I/II; 3PG, 3-phosphoglycerate; α-KG, alpha ketoglutarate.