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. 2022 Apr 21;15(5):507. doi: 10.3390/ph15050507

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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hTopo I and hTopo II assays. (A) hTopo I relaxation assay. hTopo I was exposed to DMSO (CTRL) or compounds 1 and 6 at the concentration of 1 μM, then the products of hTopo I reaction were visualized on agarose gel; (B) hTopo II decatenation assay. hTopo II was exposed to DMSO (CTRL) or compounds 1 and 6 at the concentration 1 μM. The hTopo II reaction products were visualized on agarose gel. pHOT1, supercoiled plasmid DNA; kDNA, kinetoplast DNA; CTRL, control (DMSO); 1 and 6, tested compounds.