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. 2022 Apr 21;15(5):507. doi: 10.3390/ph15050507

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Actin immunofluorescence studies. MCF-7 cells were exposed to compound 6 (used at its IC₅₀ value), with 0.1 μM Latrunculin A (LA) or with a vehicle (CTRL) for 24 h. Then the cells were further processed, observed and imaged under the inverted fluorescence microscope at 40× magnification. CTRL cells showed a regular arrangement and organization of the actin cytoskeleton. MCF-7 cells exposed to LA and, as well as those treated with compound 6, showed an irregular arrangement and organization of the actin system. Panels (A): nuclear stain with DAPI (λ_ex/λ_em = 350/460 nm); Panels (B): β-actin (Alexa Fluor^® 568; λ_ex/λ_em = 644/665 nm); Panels (C): show a merge. Representative fields are shown.