Table 3.
IC50 values of Au metal complexes (1–6), Cisplatin and Latrunculin A, expressed in μM, related to their anticancer activity against different breast cancer cells (MDA-MB-231, MCF-7 and SkBr3) and cytotoxicity against normal cells (MCF-10A and Hek-293). The means ± standard deviations are shown.
| IC50 (µM) | |||||
|---|---|---|---|---|---|
| Compounds | MDA-MB-231 | MCF-7 | SkBr3 | MCF-10A | Hek-293 |
| Cisplatin | 28.7 ± 0.4 | 35.8 ± 0.7 | 7.4 ± 0.9 | 81.3 ± 0.6 | 16.3 ± 0.9 |
| Latrunculin A | 2.4 × 10−2 ± 0.9 | 0.14 ± 1.0 | 0.7 ± 1.2 | 4.5 × 10−2 ± 1.2 | 9.3 × 10−2 ± 0.6 |
| 1 | 15.8 ± 0.7 | 29.9 ± 1.1 | 83.0 ± 1.0 | >200 | >200 |
| 2 | 22.6 ± 1.1 | 30.6 ± 0.7 | 38.4 ± 0.4 | 39.6 ± 0.5 | >200 |
| 3 | 2.2 ± 1.1 | 3.3 ± 1.4 | 10.9 ± 0.7 | 13.3 ± 1.0 | 39.0 ± 0.9 |
| 4 | 3.0 ± 0.7 | 9.4 ± 0.6 | 2.6 ± 0.7 | 5.2 ± 0.9 | 7.6 ± 1.0 |
| 5 | 58.5 ± 1.2 | 21.9 ± 0.5 | 58.9 ± 1.2 | 27.8 ± 0.7 | >200 |
| 6 | 16.8 ± 1.2 | 1.2 ± 0.3 | 2.3 ± 0.9 | 24.4 ± 0.9 | 32.5±1.1 |