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. 2022 Apr 27;15(5):540. doi: 10.3390/ph15050540

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Inhibition effect, dose-response curve, and inhibition mode of D-CDP1 and D-CDP7 over SARS-CoV-2 3CL^pro. (A): Normalised activity and inhibition of SARS-CoV-2 3CL^pro under D-CDP1 influence. (B): Normalised activity and inhibition of SARS-CoV-2 3CL^pro under D-CDP7 influence. (C): Dose-response curve of D-CDP1 and SARS-CoV-2 3CL^pro. The normalised response [%] of SARS-CoV-2 3CL^pro is plotted against the log of the D-CDP1 concentration. (D): Dose-response curve of D-CDP7 and SARS-CoV-2 3CL^pro. (E): Lineweaver-Burk plot for D-CDP1 inhibition of SARS-CoV-2 3CL^pro. [S] is the substrate concentration; v is the initial reaction rate. (F): Lineweaver-Burk plot for D-CDP7 inhibition of SARS-CoV-2 3CL^pro. Data shown are the mean ± SD from three independent measurements (n = 3).