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. 2022 Apr 27;15(5):540. doi: 10.3390/ph15050540

Figure 7.

Figure 7

SARS-CoV-2 3CLpro binding site. (A): Cartoon representation of the protease in complex with the L-CDP1 peptide (cartoon/sticks); the side chain of the catalytic residues His41 and Cys145 are shown in sticks representation. (B): Surface representation of the 3CLpro complex with the L-CDP1 peptide (cartoon/sticks). The interaction interface of the peptide with the substrate-binding sites, which is blocked by the peptide, is shown according to S1, S2, and S4. (C): Cartoon representation of the protease in complex with the L-CDP7 peptide (cartoon/sticks); the side chain of the catalytic residues His41 and Cys145 are shown in sticks representation. (D): Surface representation of the 3CLpro complex with the L-CDP7 peptide (cartoon/sticks). The interaction interface of the peptide with the substrate-binding sites that are blocked by the peptide is shown according to S1’, S2, and S4.