Table 8.

Niosomes loaded with herbal bioactive.

Herbal Medicine-Loaded Niosomes	Plant Source	Limitations of Free Drugs	Results and Outcomes	References
Permacoce hispida-loaded niosome	Permacoce hispida-	Poor stability and bioavailability	Improved stability, bioavailability, sustained release, and permeability in vitro. Enhanced anti-tuberculosis in vitro.	[136]
Embelin-loaded niosome	Embelia ribes Burm.	Poor stability and bioavailability	Improved stability, bioavailability, sustained release, and biocompatibility in vitro. Upgraded streptozotocin-induced diabetes in Albino Wistar rats with potential antioxidant activity.	[137]
Lawsone-loaded niosome	Persian Henna, Lawsonia inermis	Poor stability and bioavailability	Improved stability, bioavailability, sustained release, and in vitro permeability. Significantly improved the antitumor activity in MCF-7 cells in vitro.	[138]
Rosemarinic acid-loaded niosome	Rosmarinus officinalis	Limited drug release and drug stability	Improved sustained delivery of Niosomal gel of rosmarinic acid to bacteria (Propionibacterium acne and Staphylococcus aureus) infected cells in vitro (anti-acne vulgaris). Improved delivery of naturally occurring antimicrobial and anti-inflammatory agents, in deeper tissues of skin in vivo using Swiss albino mice.	[139]
Nerium oleander -loaded niosome	Nerium oleander	Limited antioxidant activity and bioavailability	Improved cell effectiveness and tolerability of active substances. Improved in vitro cytotoxicity toward cervical and alveolar cancer cells (HeLa and A549) using MTT assay. Displayed potential antioxidant activity in vitro using DPPH radical scavenging assay.	[140]