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. 2022 May 17;27(10):3197. doi: 10.3390/molecules27103197

Figure 6.

Figure 6

Biological activity of fucoidan on THP-1 cells. (A): Percentages of cell viability and proliferation on THP-1 macrophages subjected to various concentrations of fucoidan exposed for 24 h. (B): THP-1 monocyte migration assessed using a transwell chamber after 3 h stimulation with or without MCP-1 in the presence or absence of vehicle or fucoidan (50 µg/mL). (C): mRNA expression level of MCP-1 and ICAM-1 evaluated in THP-1 macrophages post treatment with fucoidan (50 µg/mL), vehicle, or alone for 24 h. Then cells were induced with or without IFN-γ for 3 h. Data were presented as mean ±SEM of triplicate three/two independent experiments (n = 9 for (A,B) and n = 6 for (C) and the p-values were non-significant (ns), ** p < 0.001, *** p < 0.0005 and **** p < 0.0001.