Table 3.
Genotype and allele distributions among the control, HDP, GH, PE, and SPE groups.
| Control | HDP | GH | PE | SPE | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (n = 254) | (n = 196) | (n = 78) | (n = 106) | (n = 12) | ||||||||
| Variants | p-Values | p-Values | p-Values | p-Values | ||||||||
| rs13120303 | Genotype | AA | 45 (0.177) | 31 (0.158) | 0.111 | 12 (0.154) | 0.162 | 17 (0.160) | 0.265 | 2 (0.167) | 0.995 | |
| AG | 106 (0.417) | 101 (0.515) | 42 (0.538) | 54 (0.509) | 5 (0.417) | |||||||
| GG | 103 (0.406) | 64 (0.327) | 24 (0.308) | 35 (0.330) | 5 (0.417) | |||||||
| Dominant model | AA | 45 (0.177) | 31 (0.158) | 0.594 | 12 (0.154) | 0.633 | 17 (0.160) | 0.701 | 2 (0.167) | 0.926 | ||
| GG + AG | 209 (0.823) | 165 (0.842) | 66 (0.846) | 89 (0.840) | 10 (0.833) | |||||||
| Recessive model | GG | 103 (0.406) | 64 (0.327) | 0.086 | 24 (0.308) | 0.120 | 35 (0.330) | 0.180 | 5 (0.417) | 0.939 | ||
| AG + AA | 151 (0.594) | 132 (0.673) | 54 (0.692) | 71 (0.670) | 7 (0.583) | |||||||
| Allele | A | 196 (0.386) | 163 (0.416) | 0.362 | 66 (0.423) | 0.405 | 88 (0.415) | 0.464 | 9 (0.375) | 0.915 | ||
| G | 312 (0.614) | 229 (0.584) | 90 (0.577) | 124 (0.585) | 15 (0.625) | |||||||
| rs4541465 | Genotype | CC | 59 (0.232) | 42 (0.214) | 0.375 | 14 (0.179) | 0.199 | 24 (0.226) | 0.652 | 4 (0.333) | 0.629 | |
| CT | 117 (0.461) | 103 (0.526) | 45 (0.577) | 54 (0.509) | 4 (0.333) | |||||||
| TT | 78 (0.307) | 51 (0.260) | 19 (0.244) | 28 (0.264) | 4 (0.333) | |||||||
| Dominant model | CC | 59 (0.232) | 42 (0.214) | 0.650 | 14 (0.179) | 0.325 | 24 (0.226) | 0.904 | 4 (0.333) | 0.421 | ||
| TT + CT | 195 (0.768) | 154 (0.786) | 64 (0.821) | 82 (0.774) | 8 (0.667) | |||||||
| Recessive model | TT | 78 (0.307) | 51 (0.260) | 0.276 | 19 (0.244) | 0.281 | 28 (0.264) | 0.415 | 4 (0.333) | 0.847 | ||
| CT + CC | 176 (0.693) | 145 (0.740) | 59 (0.756) | 78 (0.736) | 8 (0.667) | |||||||
| Allele | C | 235 (0.463) | 187 (0.477) | 0.667 | 73 (0.468) | 0.907 | 102 (0.481) | 0.650 | 12 (0.500) | 0.720 | ||
| T | 273 (0.537) | 205 (0.523) | 83 (0.532) | 110 (0.519) | 12 (0.500) | |||||||
| rs13152225 | Genotype | AA | 8 (0.031) | 3 (0.015) | 0.072 | 2 (0.026) | 0.201 | 1 (0.009) | 0.164 | 0 (0.000) | 0.623 | |
| AG | 59 (0.232) | 63 (0.321) | 26 (0.333) | 33 (0.311) | 4 (0.333) | |||||||
| GG | 187 (0.736) | 130 (0.663) | 50 (0.641) | 72 (0.679) | 8 (0.667) | |||||||
| Dominant model | AA | 8 (0.031) | 3 (0.015) | 0.270 | 2 (0.026) | 0.791 | 1 (0.009) | 0.222 | 0 (0.000) | 0.533 | ||
| GG + AG | 246 (0.969) | 193 (0.985) | 76 (0.974) | 105 (0.991) | 12 (1.000) | |||||||
| Recessive model | GG | 187 (0.736) | 130 (0.663) | 0.093 | 50 (0.641) | 0.104 | 72 (0.679) | 0.273 | 8 (0.667) | 0.595 | ||
| AG + AA | 67 (0.264) | 66 (0.337) | 28 (0.359) | 34 (0.321) | 4 (0.333) | |||||||
| Allele | A | 75 (0.148) | 69 (0.176) | 0.250 | 30 (0.192) | 0.181 | 35 (0.165) | 0.553 | 4 (0.167) | 0.798 | ||
| G | 433 (0.852) | 323 (0.824) | 126 (0.808) | 177 (0.835) | 20 (0.833) | |||||||
| rs67448487 | Genotype | GG | 184 (0.724) | 132 (0.673) | 0.060 | 51 (0.654) | 0.058 | 72 (0.679) | 0.370 | 9 (0.750) | 0.803 | |
| GA | 61 (0.240) | 62 (0.316) | 27 (0.346) | 32 (0.302) | 3 (0.250) | |||||||
| AA | 9 (0.035) | 2 (0.010) | 0 (0.000) | 2 (0.019) | 0 (0.000) | |||||||
| Recessive model | GG | 184 (0.724) | 132 (0.673) | 0.241 | 51 (0.654) | 0.231 | 72 (0.679) | 0.389 | 9 (0.750) | 0.846 | ||
| GA + AA | 70 (0.276) | 64 (0.327) | 27 (0.346) | 34 (0.321) | 3 (0.250) | |||||||
| Dominant model | AA | 9 (0.035) | 2 (0.010) | 0.086 | 0 (0.000) | 0.092 | 2 (0.063) | 0.405 | 0 (0.000) | 0.507 | ||
| GG + GA | 245 (0.965) | 194 (0.990) | 78 (1.000) | 104 (0.937) | 12 (1.000) | |||||||
| Allele | G | 429 (0.844) | 326 (0.832) | 0.603 | 129 (0.827) | 0.600 | 176 (0.830) | 0.633 | 21 (0.875) | 0.686 | ||
| A | 79 (0.156) | 66 (0.168) | 27 (0.173) | 36 (0.170) | 3 (0.125) | |||||||
The frequencies are shown in parentheses. p-values were determined in comparison to the control group by Fischer’s exact test. p values < 0.05 are considered to be statistically significant. HDP: hypertensive disorders of pregnancy; GH: gestational hypertension; PE: pre-eclampsia; SPE: superimposed pre-eclampsia.