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. 2022 May 19;14(10):2075. doi: 10.3390/polym14102075

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Two-dimensional (2D) reconstructed microtomographic images in transaxial and coronal sections of the bone defects in rat calvaria at 14 and 42 days, respectively. Defect filled with biomaterial (G1/B), biocomplex consisting of biomaterial plus heterologous fibrin biopolymer (G2/BFB), biomaterial and PBM (G3/B + PBM), and biocomplex consisting of biomaterial plus heterologous fibrin biopolymer and photobiomodulation with low-level laser therapy (G4/BFB + PBM). Bone formation (blue arrow) and biomaterial particles (red arrow).