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. 2022 May 19;14(10):2075. doi: 10.3390/polym14102075

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Histological sections of the edge (A’,A”) and center (B’,B”) of the bone defect of rat calvaria stained by Picrosirius-red under polarized light at 14 and 42 days ((A,B), respectively). Biomaterial (G1/B); biocomplex consisting of biomaterial plus heterologous fibrin biopolymer (G2/BFB); biomaterial and PBM (G3/B + PBM); and biocomplex consisting of biomaterial plus heterologous fibrin biopolymer and photobiomodulation with low-level laser therapy (G4/BFB + PBM). RGB green-yellow-red colors. Mature bone, type I collagen fibers: yellowish-green color; immature bone, type III collagen fibers: reddish color. Dashed line = edge of remaining bone; B = synthetic biomaterial particles (dark background); asterisk = collagen fibers in advanced maturation phase. Original magnification × 10, scale bar 200 µm.