Table 5.
Various Alg-based hydrogel carriers used in drug delivery.
| Delivery Types | Carriers | Drug | Properties | Ref. |
|---|---|---|---|---|
| Oral | Kefiran-Alg gel microspheres | Ciprofloxacin | pH-responsive, sustained release and antimicrobial | [218] |
| Ag-Alg | Tanic acid | Small size, slow drug release, antibacterial function of Ag ions | [146] | |
| Ag-Alg | BSA | Remote release | [145] | |
| Alg hydrogel/chitosan micelles | Emodin | Small size, pH-sensitive, and sustained release | [219] | |
| Alg based-hydrogels | Diclofenac sodium | Semi-interpenetrating polymer network, pH-sensitive, colon-targeted, and antimicrobial | [220] | |
| Alg/carboxymethyl chitosan composite gel beads | Bovine serum albumin | pH-sensitive, long swelling time and sustained release | [221] | |
| Chitosan-Alg based microgel | polyphenols | pH-responsive, physicochemical stabilities and sustained release | [222] | |
| Colon specific | Guar gum succinate-Alg beads | Ibuprofen | pH-dependent swelling behavior, almost no cytotoxicity | [229] |
| Portulaca oleracea polysaccharide-Alg-borax hydrogel beads | 5-fluorouracil | pH responsive, for colorectal cancer | [230] | |
| Alg-chitosan microspheres |
Icariin | pH responsive and high retention in colon, anti-inflammatory, for colonic mucosal injury | [231] | |
| Chitosan, nanocellulose and Alg based polymeric system | 5-Fluorouracil Levamisole hydrochloride |
pH dependent release and enzymatic degradation, for colon cancer | [232] | |
| Transdermal | Alg hydrogels | Vitamin D3 | Highly porous (89.2 ± 12.5%) and biodegradable. Hemo- and cyto-compatible, for wound dressing | [233] |
| Ca-Alg-PEGMA Hydrogels | Anti-TGF-β antibodies | High mechanical strength, biocompatible, and biodegradable, for wound healing | [234] | |
| Chitosan/Alg hydrogels | Alpha-tocopherol | Biodegradable, for skin injuries | [235] | |
| Gallic acid modified Alg self-adhesive hydrogel |
Caffeine | Highly porous and excellent elasticity | [236] | |
| Alg/gum acacia hydrogels | ZnO2 nanoparticles | Biocompatible, antibacterial, anti-inflammatory, for wound healing | [237] | |
| K-carrageenan/Alg | Silver nanoparticles | Sustained release and antibacterial, for wound dressing | [238] | |
| Intravenous | Fe3O4/polyethyleneimine/Alg | Fe3O4 | Enhanced magnetic resonance (MR) imaging | [239] |
| Glycyrrhizin/Alg | Antioxidant quercetin | Improved liver targeting and therapeutic efficacy | [240] | |
| Intranasal | Alg | Ropinirole hydrochloride | High encapsulation efficiency, safe to nasal epithelium. | [241] |
| Lipopolysaccharide | Induce an effective systemic and mucosal immune response | [242] | ||
| Alg/CS | PPE17 antigen | Induce strong immune response | [243] |