Table 1.
Box–Behnken DOE of independent variables (X1, X2, and X3) and their influences on responses (Y1, Y2, and Y3). All values are expressed as mean ± S.D (n = 3).
| Film Code | Pullulan (mg, X1) |
Maltodextrin (mg, X2) |
Propylene Glycol (%, X3) |
Release at 5 min (Y1, %) |
D-Time (Y2, s) |
Tensile Strength (Y3, MPa) |
|---|---|---|---|---|---|---|
| F1 | 300 | 50 | 25 | 94.3 ± 1.7 | 20.5 ± 1.9 | 4.1 ± 2.6 |
| F2 | 400 | 50 | 20 | 90.3 ± 1.5 | 28.2 ± 3.7 | 10.4 ± 2.0 |
| F3 | 400 | 0 | 25 | 85.2 ± 4.2 | 31.7 ± 2.7 | 8.6 ± 8.1 |
| F4 | 500 | 50 | 25 | 82.9 ± 1.3 | 40.2 ± 3.2 | 7.6 ± 3.5 |
| F5 | 300 | 50 | 15 | 92.0 ± 5.2 | 22.2 ± 2.3 | 11.8 ± 7.4 |
| F6 | 300 | 0 | 20 | 87.2 ± 2.5 | 24.7 ± 1.4 | 10.6 ± 4.6 |
| F7 | 400 | 100 | 25 | 94.8 ± 4.8 | 25.2 ± 3.5 | 5.0 ± 4.0 |
| F8 | 500 | 0 | 20 | 80.6 ± 2.4 | 44.5 ± 3.5 | 14.6 ± 2.1 |
| F9 | 300 | 100 | 20 | 99.8 ± 0.5 | 18.3 ± 1.9 | 6.7 ± 5.4 |
| F10 | 400 | 100 | 15 | 92.0 ± 5.2 | 27.2 ± 3.1 | 15.7 ± 0.4 |
| F11 | 500 | 100 | 20 | 87.9 ± 3.0 | 36.2 ± 3.7 | 9.9 ± 6.5 |
| F12 | 500 | 50 | 15 | 82.2 ± 1.0 | 42.2 ± 5.9 | 16.4 ± 1.1 |
| F13 | 400 | 0 | 15 | 84.0 ± 1.2 | 33.8 ± 3.1 | 17.1 ± 2.0 |
Amounts of other ingredients, such as aspartame, mannitol, drug, and distilled water (10 mL) were kept constant.