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. 2022 Apr 25;15(5):527. doi: 10.3390/ph15050527

Figure 4.

Figure 4

Morphine accumulates in the retina, but not the hypothalamus. (A) Retinal morphine concentrations exceed hypothalamic morphine concentrations at 1 (ZT 1) and 11 (ZT 11) hours following chronic morphine exposure (6 days of morphine treatment). (B) Morphine accumulates in the retina, but not the hypothalamus following chronic morphine exposure. Two-way ANOVA with a Tukey post hoc adjustment was performed on a natural logarithmic (ln) scale. Data are presented as the mean ± SEM with 5–17 mice per group (* = p < 0.01, *** = p < 0.0001).

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