Figure 1.

Henipavirus structure and genome organization. (A) Schematic representation of henipaviruses single-stranded negative-sense RNA genome containing six genes encoding the nucleoprotein (N), the phosphoprotein (P), matrix protein (M), the fusion protein (F), the attachment glycoprotein (G), and the polymerase protein (L). Additionally, the henipavirus P gene encodes three nonstructural proteins: two (V and W) are generated by the addition of one or two G nucleotides in the editing site of the P gene, and the C protein is encoded by an alternative open reading frame (ORF); (B) Schematic representation of an henipavirus particle. The described structural proteins form the pleomorphic particle. The ribonucleic (RNP) complex is formed by N, P, L proteins and the viral RNA.