Table 4.
Upregulated and downregulated miRNAs in maternal saliva.
| miRNA Name | Fold Change (FC) |
p-Value | False Discovery Rate p-Value (FDR) |
|---|---|---|---|
| hsa-miR-505 ↓ | 0.335 | 0.0002 | 0.0396 |
| hsa-miR-616 ↓ | 0.434 | 0.0123 | 0.1873 |
| hsa-miR-618 ↑ | 7.141 | 0.0002 | 0.0396 |
| hsa-miR-206 ↑ | 3.985 | 0.0005 | 0.0514 |
| hsa-miR-376a ↑ | 5.870 | 0.0008 | 0.0671 |
| hsa-miR-517c ↑ | 2.788 | 0.0015 | 0.0989 |
| hsa-miR-133a ↑ | 3.703 | 0.0041 | 0.1599 |
| hsa-miR-512 ↑ | 23.295 | 0.0044 | 0.1599 |
| hsa-miR-302d ↑ | 14.427 | 0.0046 | 0.1599 |
| hsa-miR-520b ↑ | 2.755 | 0.0051 | 0.1599 |
| hsa-miR-1254 ↑ | 5.443 | 0.0054 | 0.1599 |
| hsa-miR-133b ↑ | 5.634 | 0.0057 | 0.1599 |
| hsa-miR-1285 ↑ | 40.956 | 0.0095 | 0.1859 |
| hsa-miR-635 ↑ | 2.178 | 0.0102 | 0.1859 |
| hsa-miR-551b ↑ | 2.614 | 0.0106 | 0.1859 |
| hsa-miR-548b-5p ↑ | 5.692 | 0.0110 | 0.1859 |
| hsa-miR-1256 ↑ | 2.169 | 0.0110 | 0.1859 |
| hsa-miR-302c ↑ | 2.622 | 0.0111 | 0.1859 |
| hsa-miR-184 ↑ | 4.817 | 0.0118 | 0.1873 |
| hsa-miR-548c-5p ↑ | 4.912 | 0.0131 | 0.1909 |
FC (Fold Change), p-value, and FDR (False Discovery Rate) of the 20 miRNAs with significantly different expression levels in OB vs. NW. Data were analyzed with a multiple linear regression analysis adjusted for gestational age at saliva withdrawal, age, smoking habits, and GDM association. Results are presented in descending order of statistical significance. (↓: downregulated; ↑: upregulated miRNA in OB vs. NW).