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. 2022 May 16;14(5):1060. doi: 10.3390/v14051060

Figure 2.

Figure 2

Humoral immune response against RBD protein in animals: (A) Animals’ sera’s IgG titers 2 weeks after boost injections according to ELISA using RBD, S-trimer, and SARS-CoV-2 virus lysate (geometric mean ± SD). (B) Virus-neutralizing antibody titers evaluated by Victoria/1/2020 SARS-CoV-2 virus-neutralization test (100 TCID50). Horizontal lines represent geometric mean values; Statistical significance was calculated using the Kruskal–Wallis test (*** p < 0.001; ns, not significant (p > 0.05)). Negative samples (titer < 1/10) were taken as 1.