Table 6.
Parameters derived from the non–compartmental analysis of the time–activity curves of [18F]FLUDA in different brain regions of pigs treated with (toz) and without (veh) the A2AAR specific antagonist tozadenant.
| Brain Region | Time–to–Peak Time (min) |
TAC Peak Value (SUV) |
AUC0–90 min (SUV min) |
MRT (min) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Veh | Toz | p–Value | Veh | Toz | p–Value | Veh | Toz | p–Value | Veh | Toz | p–Value | |
| Striatum | 5.5 ± 2.8 | 1.6 ± 1.7 | 0.05 | 1.3 ± 0.1 | 0.9 ± 0.2 | 0.03 | 61 ± 9 | 34 ± 5 | 0.01 | 31 ± 2 | 30 ± 2 | 0.38 |
| Cerebellum | 1.5 ± 0.0 | 1.0 ± 0.5 | 0.43 | 1.0 ± 0.2 | 0.9 ± 0.3 | 0.32 | 30 ± 2 | 27 ± 5 | 0.27 | 31 ± 1 | 32 ± 2 | 0.22 |
| Midbrain | 2.5 ± 1.0 | 1.3 ± 1.0 | 0.11 | 1.1 ± 0.1 | 1.0 ± 0.3 | 0.30 | 27 ± 2 | 26 ± 6 | 0.35 | 27 ± 1 | 29 ± 2 | 0.17 |
| Cortex | 1.5 ± 0.0 | 1.3 ± 1.0 | 0.40 | 1.0 ± 0.2 | 0.9 ± 0.3 | 0.29 | 30 ± 2 | 29 ± 5 | 0.42 | 30 ± 1 | 32 ± 1 | 0.07 |
p–value—Student’s t–test.