Table 2.

Composite score based on the nine common discriminant biomarkers for the early period (24 h to 15 days range) in urinary C18 positive profiles for reduced models 1 and 2.

Model	Individuals of Model 1 and Model 2 (24 h, 48 h, 5 d, 15 d)		Metabolite	FDR	Fold Change	Boxplot
Validation parameters	R2Y(cum) = 84.2% Q2(cum) = 81.9% p value = 5.41155 × 10−34	Very good permutation test	M137T39	1.1906 × 10−10	20.262
Composite score equation	Score = (1.10234 × 10−10 × M184T138) + (−5.44577 × 10−11 × M137T39) + (−2.31758 × 10−9 × M254T148) + (−1.40745 × 10−8 × M236T148) + (9.49838 × 10−12 × M153T134) + (−2.37778 × 10−8 × M276T148) + (2.55785 × 10−9 × M136T133) + (−4.47195 × 10−9 × M366T259) + (1.52073 × 10−9 × M108T133) + 0.747992		M236T148	4.0973 × 10−21	15.462
			M254T148	4.0973 × 10−21	14.841
			M276T148	3.4084 × 10−19	11.878
ROC curve		AUC = 1	M366T259	5.2434 × 10−14	8.2975
			M136T133	7.2673 × 10−7	0.4324
			M153T134	3.8045 × 10−6	0.60654
			M108T133	1.529 × 10−5	0.651
			M184T138	2.9739 × 10−3	0.69533