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Label-free detection of exosomes with the nPLEX sensor. (a) A scanning electron image of the periodic nanoholes in the nPLEX sensor. (b) A prototype of the nPLEX imaging system. (c) Schematic to represent the changes in transmission spectra to show the exosome detection with the nPLEX device. (d) Scanning electron microscopy image showing the exosome capture near the nanohole array. (Reproduced from Im H. et al. [82]. Copyright 2014, Nat Biotechnol.).
