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. 2022 May 16;14(10):2080. doi: 10.3390/nu14102080

Figure 8.

Figure 8

Effects of NK151 and NK175 on iGm-induced depression and colitis in mice. (A) Experimental protocol. (B) Effects on depressive-like behaviors in the EMPT (a), LDTT (b), TST (c), and FST (d). (C) Effects on hippocampal BDNF+NeuN+, NF-κB+Iba1+, claudin-5+ cell populations (a), IL-1β (b), IL-6 (c), and IL-10 values (d). (D) Effects on blood corticosterone (a), IL-1β (b), IL-6 (c), IL-10 (d), endotoxin (e), and creatinine levels (f). (E) Effects on colonic myeloperoxidase (MPO) activity (a), IL-1β (b), IL-6 (c), and IL-10 expression (d), and NF-κB+CD11c+, cladudin-1+, and occludin+ cell populations (e). (F) Effects on fecal endotoxin level. Normal control (NC) was treated with saline instead of test agents and iGm. Test agents (veh, vehicle alone; 151, 1 × 109 CFU/mouse of NK151; 173, 1 × 109 CFU/mouse of NK173; 175, 1 × 109 CFU/mouse of NK175) were orally given in iGm-treated mice daily for 5 days. Groups with same letters are not significantly different (n = 8, p < 0.05).