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. 2022 Apr 19;15(5):495. doi: 10.3390/ph15050495

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Duration of spontaneous recurrent seizures (SRSs) in epileptic rats treated with cannabidiol (CBD) at 12 mg/kg, 120 mg/kg or with medium-chain triglyceride (MCT) oil. Rats (n = 30) were treated with CBD 12 mg/kg (n = 10, 2 of which did not display SRSs and were attributed a 0 value), CBD 120 mg/kg (n = 10, 5 of which did not display SRSs and were attributed a 0 value), or MCT oil (n = 10, 1 of which did not display SRSs and were attributed a 0 value). In (A), CBD at 120 mg/kg significantly decreased (Tukey test; * p < 0.05, PRE-CBD 120 vs. CBD 120; ° p < 0.05, MCT OIL vs. CBD 120) the total number of SRSs. The high dose of CBD displayed no significant effects when stages (ST.) 0–3 (B) and ST. 4–5 (C) SRSs were considered separately.