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. 2022 Apr 19;15(5):495. doi: 10.3390/ph15050495

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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PPARγ immunoreactivity in hippocampal regions of controls and rats treated with cannabidiol (CBD) or with medium-chain triglyceride (MCT) oil. Non-treated controls (CTRL NT, n = 6) and epileptic animals (A) treated with CBD at high dose (CBD 120, n = 6), CBD at low dose (CBD 12, n = 6), or MCT oil (MCT OIL, n = 6) were used to determine the levels of PPARγ in CA3 Py (B), CA1 Py (C), and Sub (D). * p < 0.05, *** p < 0.001, CBD 12 or CBD120 vs. CTRL NT; ° p < 0.05, CBD 120 vs. MCT OIL; # p < 0.05, CBD 120 vs. CBD 12; Holm-Šidák test. CTRL NT, non-treated control; CBD, cannabidiol. CA3 Py, Stratum pyramidalis of Cornu Ammonis 3; CA1 Py, Stratum pyramidalis of Cornu Ammonis 1; Sub, Subiculum. Scale: 0.1 mm.