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. 2022 May 12;14(5):1043. doi: 10.3390/pharmaceutics14051043

Figure 12.

Figure 12

Mechanism of death due to apoptosis (A) and necrosis (B) induced after treatment of H. capsulatum EH-315 with 7, 11, and 32, in addition to the drug controls AmB and ITZ, compared with the untreated control. The AmB induced cell death by apoptosis, whereas ITZ, 7, 11, and 32 induced death by necrosis. * p < 0.05; ** p < 0.01.