Table 4.

Values of CC₅₀ (µg/mL) and SI for the A549 cell line in the monolayer and the 3D model treated with nitrofuran and indole derivatives.

	A549
	Monolayer			Spheroid
		EH-315	ATCC G217-B		EH-315	ATCC G217-B
Compounds	CC50 (µg/mL)	SI	SI	CC50 (µg/mL)	SI	SI
3	231.2	118.56	59.28	>250	>128.20	>64.10
4	29.50	30.10	7.56	62.96	64.24	16.14
5	30.11	125.45	15.44	43.01	179.20	22.05
7	8.58	70.32	8.75	>250	>2049.18	>255.1
9	23.41	23.88	6.00	17.25	17.60	4.42
10	38.67	4.95	4.95	32.97	4.22	4.22
11	12.24	50.16	25.50	56.06	229.75	116.79
12	>250	>32.01	>32.01	104.8	13.41	13.41
14	33.44	8.83	4.4	27.61	7.07	3.53
20	81.41	10.42	10.42	81.41	10.42	10.42
21	40.00	5.12	5.12	40.00	5.12	5.12
32	81.41	20.87	20.87	81.41	20.76	20.76
33	12.26	6.28	3.14	13.22	6.77	1.69
39	42.79	5.47	2.73	60.5	7.74	3.87

CC₅₀—concentration that inhibits cell proliferation by 50%; SI—selectivity index (CC₅₀/MIC₉₀).