Table 5.

Values of CC₅₀ (µg/mL) and SI for the MRC-5 cell line in the monolayer and the 3D model treated with nitrofuran and indole derivatives.

	MRC-5
	Monolayer			Spheroid
		EH-315	ATCC G217-B		EH-315	ATCC G217-B
Compounds	CC50 (µg/mL)	SI	SI	CC50 (µg/mL)	SI	SI
3	>250	>128.20	>64.10	>250	>128.20	>64.10
64	135.2	137.95	34.66	>250	> 255.10	>64.10
5	39.76	165.66	20.38	81.41	339.20	41.74
7	71.24	583.93	72.69	73.50	602.45	75.00
9	47.23	48.19	12.11	169.6	173.06	43.48
10	215.4	27.58	27.58	57.92	7.41	7.41
11	62.56	256.39	130.33	67.79	277.82	141.22
12	228.0	29.19	29.19	76.12	9.74	9.74
14	26.8	6.87	3.43	7.68	1.96	0.98
20	20.39	2.61	2.61	25.35	3.57	3.57
21	33.77	4.32	4.32	52.34	6.70	6.70
32	24.7	6.33	6.33	26.14	6.70	6.70
33	18.74	9.56	4.78	14.03	7.19	3.59
39	40.00	5.12	2.56	40.00	5.12	2.56

CC₅₀—concentration that inhibits cell proliferation by 50%; SI—selectivity index (CC₅₀/MIC₉₀).