Figure 3.

Lung virus titers from male BALB/c mice. The mice received 2 mg/kg or 200 mg/kg probenecid 24 h before infection (prophylaxis) or 24 h pi (treatment). The mice were i.n. infected with 10⁶ PFU of RSV A2. On days 3, 5, and 7 pi, the lungs were harvested, and virus titers were determined by plaque assay having a limit of detection of 1 × 10² PFU/mL. There is significant (**** p < 0.0001) reduction in lung viral titers with all probenecid treatments compared to control (PBS).