Table 4.

The relative quantitation ratios (log2) of proteins in the TGF beta signaling pathway and proteins involved in melanogenesis upon treatment with TILI-2 from proteomics data.

Function	Order	Protein Name	Gene Name	t-Test (p)	Average Log2 Expression Value
					Untreated Cell	TILI-2 Treated Cell
TGF-beta pathway	1	Mitogen-activated protein kinase 1	MK01_MOUSE	0.9510	14.99	15.01
	2	Mitogen-activated protein kinase kinase kinase 7-interacting protein 1	TAB1_MOUSE	0.9878	15.62	15.63
	3	Mothers against decapentaplegic homolog 5	SMAD5_MOUSE	0.7259	15.18	15.26
	4	Transforming growth factor beta-3	TGFB3_MOUSE	0.8527	14.79	14.86
	5	GTPase HRas	RASH_MOUSE	0.3821	14.07	14.25
	6	Mitogen-activated protein kinase 3	MK03_MOUSE	0.6866	14.79	14.61
	7	E3 ubiquitin-protein ligase SMURF1	SMUF1_MOUSE	0.5889	12.76	14.39
	8	E3 ubiquitin-protein ligase SMURF2	SMUF2_MOUSE	0.0265	15.33	15.58
	9	Growth/differentiation factor 5	ABCBA_MOUSE	0.3343	16.03	16.39
	10	Bone morphogenetic protein 6	BMP6_MOUSE	0.3300	15.96	16.51
	11	Growth/differentiation factor 7	GDF7_MOUSE	0.5095	15.48	13.72
	12	Bone morphogenetic protein 4	BMP4_MOUSE	0.6398	15.86	16.00
	13	Activin receptor type-2A	AVR2A_MOUSE	0.6189	15.52	15.71
	14	Apoptotic protease-activating factor 1	APAF_MOUSE	0.9578	14.13	13.99
	15	Mitogen-activated protein kinase 12	MK12_MOUSE	0.5613	13.22	13.55
	16	Peptidyl-prolyl cis-trans isomerase FKBP1A	FKB1A_MOUSE	0.1541	14.53	13.37
	17	Transforming growth factor beta-2	TGFB2_MOUSE	0.0009	15.47	16.10
Melanogenesis	18	L-dopachrome tautomerase	TYRP2_MOUSE	0.1481	14.26	14.65
	19	5,6-dihydroxyindole-2-carboxylic acid oxidase	TYRP1_MOUSE	0.4880	16.09	16.28
	20	Paired box protein Pax-3	PAX3_MOUSE	0.3759	13.35	11.55