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. 2022 May 6;12(5):417. doi: 10.3390/metabo12050417

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Serum bile acid concentrations in extreme weight loss responders to RYGB surgery. Principal component analyses of serum bile acid levels in good and bad responders (A,B) after RYGB surgery. Significance calculated by PERMANOVA (C) shows total unconjugated and conjugated fasting bile acid concentrations in good and bad responder groups which were further divided into primary and secondary bile acid species (D). Individual fasting bile acid concentrations shown in (E,F). Data shown as mean ± SEM. Group comparisons were performed with Student’s t-test. The symbol * indicates a p-value ≤ 0.05. CBA, conjugated bile acids; CpBA, conjugated primary bile acids; CsBA, conjugated secondary bile acids; UBA, unconjugated bile acids; UpBA, unconjugated primary bile acids; UsBA, unconjugated secondary bile acids; CA, cholic acid; CDCA, chenodeoxycholic acid; α-MCA, α-Muricholic acid; β-MCA, beta-Muricholic acid; DCA, Deoxycholic acid; HDCA, Hyodeoxycholic acid; LCA, Lithocholic acid; ω-MCA, ω-Muricholic acid; UDCA, Ursodeoxycholic acid; GCA, glycocholic acid; GCDCA, glycochenodeoxycholic acid; TCA, Taurocholic acid; TCDCA, Taurochenodeoxycholic Acid; TMCA (α+β), Tauro-muricholic acid; GLCA, glycolithocholic acid; GUDCA, Glycoursodeoxycholic acid; TDCA, Taurodeoxycholic acid; TLCA, Taurolithocholic acid; TUDCA, Tauroursodeoxycholic acid.

Serum bile acid concentrations in extreme weight loss responders to RYGB surgery. Principal component analyses of serum bile acid levels in good and bad responders (A,B) after RYGB surgery. Significance calculated by PERMANOVA (C) shows total unconjugated and conjugated fasting bile acid concentrations in good and bad responder groups which were further divided into primary and secondary bile acid species (D). Individual fasting bile acid concentrations shown in (E,F). Data shown as mean ± SEM. Group comparisons were performed with Student’s t-test. The symbol * indicates a p-value ≤ 0.05. CBA, conjugated bile acids; CpBA, conjugated primary bile acids; CsBA, conjugated secondary bile acids; UBA, unconjugated bile acids; UpBA, unconjugated primary bile acids; UsBA, unconjugated secondary bile acids; CA, cholic acid; CDCA, chenodeoxycholic acid; α-MCA, α-Muricholic acid; β-MCA, beta-Muricholic acid; DCA, Deoxycholic acid; HDCA, Hyodeoxycholic acid; LCA, Lithocholic acid; ω-MCA, ω-Muricholic acid; UDCA, Ursodeoxycholic acid; GCA, glycocholic acid; GCDCA, glycochenodeoxycholic acid; TCA, Taurocholic acid; TCDCA, Taurochenodeoxycholic Acid; TMCA (α+β), Tauro-muricholic acid; GLCA, glycolithocholic acid; GUDCA, Glycoursodeoxycholic acid; TDCA, Taurodeoxycholic acid; TLCA, Taurolithocholic acid; TUDCA, Tauroursodeoxycholic acid.