Table 5.

Summary of genetic research and tendon injuries: Glycoproteins in the ECM and elastin and fibrillin.

Type	Protein	Reference	Country	Variant	Pathology	Subjects	Controls	Comments
Glycoproteins in the ECM	Tenascin-C (TNC)	[74]	South Africa, Australia	TNC—GT dinucleotide repeats	Achilles’ tendinopathy and rupture	144	127	Association with the number of GT repeat polymorphism and the risk of tendinopathy and rupture
		[60]	South Africa, Australia	TNC rs13321, rs2104772, rs1330363	Achilles’ tendinopathy and rupture	179	339	No significant associations found among variants
		[80]	Spain	TNC rs2104772	Patellar tendon injury	15	0	No difference between severity of injury and gene variants. No controls were included
	Cartilage oligomeric matrix protein (COMP)	[75]	South Africa, Australia	COMP rs730079, rs2849450 THBS2 rs9505888	Achilles’ tendinopathy and rupture	178	340	No significant associations found among variants
Elastin and Fibrillin	Elastin (ELN) and Fibrillin (FBN)	[78]	South Africa, Australia	ELN rs2071307 FBN2 rs331079	Achilles’ tendinopathy and rupture	135	239	No association with the ELN variant and tendon pathology Significant association between the FBN2 gene variant and tendon disease
		[81]	UK	ELN rs2071307	Achilles’ tendinopathy and rupture	108	131	No association with the ELN variant and tendon pathology
		[80]	Spain	ELN rs2289630	Patellar tendon injury	15	0	No difference between severity of injury and gene variants. No controls were included

Green indicates an association and red indicates no association found.