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. 2022 May 18;14(10):2106. doi: 10.3390/nu14102106

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Sesamin promoted osteoporosis fracture healing in vivo: (A) X-ray images of the fracture femurs at different time points (the fracture sites were indicated by white arrows). (B) Three-dimensional reconstruction images of new formed callus 14 or 28 days after surgery. (C,D) Bone volume/tissue volume (BV/TV) in each group at day 14 (C) and 28 (D) post-surgery. (E) Measurements of callus area at different timepoints after surgery. (F) Analysis of biomechanical parameters including E-modulus, ultimate load and energy to failure of fractured femurs normalized to non-fractured femurs at day 28 post-surgery (n = 6; ^# p < 0.05, ^## p < 0.01 vs. Sham group; * p < 0.05, ** p < 0.01 vs. OVX group).