Table 1.
Clinical characteristics of patients with candidemia according to hospital admission due to COVID-19 or not.
| Patients with COVID-19 (n = 16) | Patents without COVID-19 (n = 72) | p-Value | |
|---|---|---|---|
| Age (years), (median (IQR)) | 73.5 (66.5–77.5) | 66 (59–76.5) | 0.077 |
| Male gender | 12 (75) | 49 (68.1) | 0.413 |
| Obesity | 4 (25) | 2 (2.8) | 0.009 |
| Diabetes mellitus | 7 (43.8) | 20 (27.8) | 0.169 |
| Heart failure | 2 (12.5) | 9 (12.5) | 0.682 |
| Chronic lung disease | 5 (31.3) | 9 (12.5) | 0.076 |
| Dementia | 0 | 7 (9.7) | 0.252 |
| Chronic liver disease | 1 (6.3) | 9 (12.5) | 0.270 |
| Chronic renal failure | 1 (6.3) | 6 (8.3) | 0.626 |
| Solid tumor | 1 (6.3) | 21 (29.2) | 0.047 |
| Hematologic malignancy | 0 | 6 (8.3) | 0.288 |
| Charlson comorbidity index, (median (IQR)) | 1 (0–3) | 2 (1–4) | 0.110 |
| Solid organ transplantation | 0 | 6 (8.3) | 0.288 |
| Hospital stay before candidemia, (median (IQR)) | 22.5 (14–53.5) | 20 (4–35) | 0.915 |
| ICU admission | 15 (93.7) | 10 (13.9) | <0.001 |
| Previous corticosteroids treatment | 14 (87.5) | 10 (13.9) | <0.001 |
| Previous tocilizumab treatment | 14 (87.5) | 10 (13.9) | <0.001 |
| Previous immunosuppressive treatment | 0 | 6 (8.3) | 0.288 |
| Previous antifungal treatment | 5 (31.3) | 19 (26.4) | 0.454 |
| Previous antibiotic treatment | 16 (100) | 62 (86.1) | 0.119 |
| Central venous catheter | 16 (100) | 53 (73.6) | 0.013 |
| Arterial catheter | 8 (50) | 16 (22.2) | 0.018 |
| Parenteral nutrition | 12 (75) | 30 (41.7) | 0.016 |
| Renal replacement therapy | 4 (26.7) | 16 (21.9) | 0.459 |
| Candida spp. previous colonization | 5 (31.3) | 15 (20.8) | 0.276 |
| Candida Score | 2 (1–2.5) | 2 (0–3) | 0.885 |
| Abdominal surgery | 1 (6.3) | 21 (29.2) | 0.047 |
| Surgery, other site | 0 | 14 (19.4) | 0.046 |
| Candidemia source | |||
| Venous catheter | 13 (81.3) | 34 (47.2) | 0.013 |
| Intraabdominal | 1 (6.3) | 15 (20.8) | 0.156 |
| Urinary tract | 1 (6.3) | 8 (11.1) | 0.316 |
| Unknown | 3 (18.7) | 22 (30.6) | 0.184 |
| Fever | 15 (93.8) | 65 (90.3) | 0.553 |
| Endophtalmitis 1 | 3 (18.7) | 5 (7.1) | 0.094 |
| Endocarditis 2 | 1 (6.3) | 5 (6.9) | 0.701 |
| Recurrent candidemia | 4 (26.7) | 3 (6.2) | 0.019 |
| Acute kidney failure | 4 (25) | 35 (48.6) | 0.073 |
| Mortality | 7 (43.8) | 42 (58.3) | 0.216 |
| Mortality attributable to candidemia | 1 (6.25) | 6 (8.3) | 0.660 |
IQR—interquartile range. 1 Fundoscopy was performed in 61 patients. 2 Echocardiography was performed in 73 patients.