. 2022 May 11;14(10):2022. doi: 10.3390/nu14102022

Table 5.

Uninfected (spontaneous) and VSV-infected cytokine production by PBLs. Effect of EGb treatment. Median is measure of average level. For every individual person and for every change in cytokine level after EGb, treatment equals $d = \log \frac{a f t e r}{b e f o r e} = \log (a f t e r) - \log (b e f o r e)$ . EGb effect is average of all $d' s$ in a group. EGb effect is than average of ratios $\frac{a f t e r}{b e f o r e}$ expressed in logs. Delta $Δ$ is measure of difference in EGb effects between AD and controls, and this statistic is the average difference between a randomly selected person from AD group and a randomly selected person from control group.

		Uninfected PBLs			VSV-Infected PBLs
TNF−α		PBLs	PBLs + EGb	EGb effect	PBLs + VSV	PBLs + VSV + EGb	EGb effect
AD	Median	27.17	1.01	−3.16	60.47	1.1	−3.73
AD	CI95	9.55; 79.21	0.23; 3.54	−4.28; −2.03	19.58; 153.66	0.31; 3.74	−4.86; −2.59
Controls	Median	49.02	17.2	−0.95	212.83	22.56	−2.01
Controls	CI95	24.88; 99.64	6.49; 41.73	−1.86; −0.36	100.85; 445.43	8.1; 63.35	−3.04; −1.28
AD vs. Controls	$Δ$	−8.14	−13.41	−1.96	−151.6	−20.93	−1.51
	CI95	−49.23; 31.88	−43.47; −2.09	−3.41; −0.56	−420.02; −7.61	−76.2; −2.35	−3.28; −0.06
	p-value (EGb effect AD vs. controls) = 0.0107				p-value (EGb effect AD vs. controls) = 0.0317
IFN−γ		PBLs	PBLs + EGb	EGb effect	PBLs + VSV	PBLs + VSV + EGb	EGb effect
AD	Median	9.84	2.69	−1.31	9.86	2.83	−1.27
AD	CI95	6.84; 14.24	1.75; 4.28	−1.83; −0.8	6.95; 12.88	1.87; 4.21	−1.69; −0.89
Control	Median	3.29	3.31	−0.01	8.66	5.05	−0.56
Control	CI95	1.84; 5.08	1.69; 6.06	−0.36; 0.28	5.02; 13.68	3.09; 7.07	−0.96; −0.23
AD vs. Controls	$Δ$	6.03	−0.72	−1.28	0.45	−2.35	−0.69
	CI95	3.48; 9.41	−3.38; 1.17	−1.95; −0.55	−4.17; 4.83	−4.21; −0.21	−1.2; −0.15
	p-value (EGb effect AD vs. controls) = 0.0003				p-value (EGb effect AD vs. controls) = 0.0127
IL−10		PBLs	PBLs + EGb	EGb effect	PBLs + VSV	PBLs + VSV + EGb	EGB effect
AD	Median	86.13	10.47	−1.9	43.49	2.37	−2.57
AD	CI95	34.77; 232.97	3.51; 34.75	−2.69; −1.18	15.73; 108.76	1; 6.58	−3.36; −1.75
Control	Median	162.87	28.76	−1.52	163.73	20.11	−1.99
Control	CI95	60.29; 356.65	10.13; 110.43	−2.27; −0.98	70.42; 369.71	8.93; 46.73	−2.63; −1.39
AD vs. Control	$Δ$	−70.75	−15.99	−0.26	−150.13	−17.55	−0.51
	CI95	−338.92; 57.65	−94.28; 14.73	−1.07; 0.52	−315.32; −13.16	−48.42; −2.18	−1.53; 0.41
	p-value (EGb effect AD vs. controls) = 0.5322				p-value (EGb effect AD vs. controls) = 0.3104
IL−1β		PBLs	PBLs + EGb	EGb effect	PBLs + VSV	PBLs + VSV + EGb	EGb effect
AD	Median	367.64	328.83	−0.11	401.33	427.88	0.08
AD	CI95	238.78; 486.76	249.2; 424.48	−0.38; 0.17	302.81; 510.61	294.89; 552.79	−0.16; 0.29
Control	Median	288.6	496.12	0.57	550.54	604.51	0.12
Control	CI95	199.13; 399.27	329.64; 706.04	0.12; 0.96	403.5; 718.55	437.85; 830.44	−0.09; 0.36
AD vs. Control	$Δ$	73.16	−190.84	−0.71	−148.62	−180.34	−0.03
	CI95	−51.88; 211.25	−398.28; 0.32	−1.17; −0.2	−337.82; −6.34	−497.08; 34.26	−0.36; 0.26
	p-value (EGb effect AD vs. controls) = 0.005				p-value (EGb effect AD vs. controls) = 0.8316
IL−15		PBLs	PBLs + EGb	EGb effect	PBLs + VSV	PBLs + VSV + EGb	EGb effect
AD	Median	22.7	39.59	0.55	23.7	39.11	0.48
AD	CI95	16.47; 31.27	30.9; 50.51	0.22; 0.91	18; 31.03	29.49; 54.57	0.21; 0.86
Control	Median	30.79	42.96	0.32	40.71	48.62	0.15
Control	CI95	23.05; 40.39	33.36; 56.07	0.04; 0.68	31.68; 54.52	35.66; 67.56	−0.08; 0.43
AD vs. Control	$Δ$	−8.58	−2.9	0.22	−15.44	−8.45	0.32
	CI95	−16.88; −0.29	−12.49; 5.47	−0.22; 0.69	−23.72; −9.17	−22.42; 3.89	−0.06; 0.69
	p-value (EGb effect AD vs. controls) = 0.3451				p-value (EGb effect AD vs. controls) = 0.0917