. 2022 May 11;14(10):2022. doi: 10.3390/nu14102022

Table 6.

Genes expression before and after EGb treatment and measure of EGb effect in AD patients and control group. Median is measure of average level. For every individual person and for every gene change of expression level after, treatment equals $d = \log \frac{a f t e r}{b e f o r e} = \log (a f t e r) - \log (b e f o r e)$ . EGb effect is average of all $d s$ in a group. EGb effect is the average of ratios $\frac{a f t e r}{b e f o r e}$ expressed in logs. Delta $Δ$ is measure of difference in EGb effects between AD and controls, and this statistic is the average difference between a randomly selected person from AD group and a randomly selected person from control group.

		Uninfected PBLs			VSV-Infected PBLs
IRF−3		PBLs	PBLs + EGb	EGb effect	PBLs + VSV	PBLs + VSV + EGb	EGB effect
AD	Median	1.65	1.78	−0.04	2.88	2.21	−0.2
AD	CI95	0.76; 4.01	0.59; 4.78	−0.95; 1.04	0.61; 9.7	1.04; 6.61	−1.41; 1.45
Control	Median	2.62	1.17	−0.82	1.95	2.53	0.25
Control	CI95	1.08; 6.3	0.61; 2.25	−1.6; 0.02	1.05; 3.73	0.98; 6.14	−0.58; 1.05
AD vs. Control	delta	−1.1	0.92	0.81	2.07	−0.18	−0.56
	CI95	−6.43; 1.22	−0.79; 3.75	−0.57; 2.13	−1.28; 9.98	−4.61; 6.35	−1.99; 1.37
	p-value	p = 0.2371			p = 0.4612
IRF−7		PBLs	PBLs + EGb	EGb effect	PBLs + VSV	PBLs + VSV + EGb	EGB effect
AD	Median	1.39	1.06	−0.42	11.78	1.83	−1.73
AD	CI95	0.58; 4.08	0.36; 3.01	−1.37; 0.72	3.31; 32.97	0.67; 7.28	−3.31; −0.14
Control	Median	2.1	0.52	−1.39	7.84	2.1	−1.34
Control	CI95	0.74; 5.9	0.29; 0.96	−2.47; −0.3	4.44; 14.53	0.71; 5.13	−2.37; −0.63
AD vs. Control	delta	−1.06	0.77	1.02	7.81	0.18	−0.35
	CI95	−5.65; 2.38	−0.37; 3.19	−0.62; 2.54	−5.26; 39.16	−3.96; 16.53	−2.12; 1.79
	p-value	p = 0.1921			p = 0.7206
Tet		PBLs	PBLs + EGb	EGb effect	PBLs + VSV	PBLs + VSV + EGb	EGB effect
AD	Median	1.32	1.12	−0.3	8.27	1.16	−1.81
AD	CI95	0.63; 2.94	0.38; 2.58	−1.09; 0.83	2.12; 24.23	0.58; 3.58	−3.13; −0.53
Control	Median	2.12	0.63	−1.16	6.66	1.79	−1.39
Control	CI95	0.85; 5.1	0.3; 1.28	−2.16; −0.21	3.89; 11.87	0.69; 4.59	−2.16; −0.63
AD vs. Control	delta	−1.23	0.59	0.88	3.76	−0.89	−0.43
	CI95	−5.11; 0.87	−0.44; 1.81	−0.53; 2.39	−5.16; 19.04	−4.57; 3.69	−2.12; 1.26
	p-value	p = 0.2264			p = 0.5552
SOCS1		PBLs	PBLs + EGb	EGb effect	PBLs + VSV	PBLs + VSV + EGb	EGB effect
AD	Median	3.51	3.09	−0.26	11.94	3.63	−1.04
AD	CI95	1.6; 8.11	1.2; 6.88	−0.9; 0.82	3.64; 32.57	1.54; 15.29	−2.42; 0.26
Control	Median	2.28	0.97	−0.86	4.57	2.37	−0.75
Control	CI95	0.94; 5.72	0.55; 1.68	−1.7; 0	2.89; 7.79	0.97; 5.17	−1.53; 0.09
AD vs. Control	delta	0.84	2.73	0.63	10.7	2.62	−0.3
	CI95	−2.86; 5.41	0.16; 6.75	−0.58; 1.89	−1.6; 34.36	−3.24; 36.4	−2; 1.48
	p-value	p = 0.2868			p = 0.6482
SOCS3		PBLs	PBLs + EGb	EGb effect	PBLs + VSV	PBLs + VSV + EGb	EGB effect
AD	Median	2.52	2.34	−0.17	3.93	2.43	−0.34
AD	CI95	1.29; 5.7	0.86; 5.73	−0.97; 0.77	0.9; 14.48	1.09; 10.14	−1.61; 0.99
Control	Median	2.26	0.68	−1.12	1.29	1.22	−0.23
Control	CI95	0.87; 4.98	0.34; 1.38	−1.92; −0.34	0.81; 2.61	0.5; 2.78	−1.06; 0.68
AD vs. Control	delta	−0.06	1.9	0.92	4.61	2	−0.17
	CI95	−2.96; 3.8	0.16; 5.99	−0.22; 2.17	−0.65; 17.48	−1.32; 23.93	−1.73; 1.56
	p-value	p = 0.1284			p = 0.8019
NFkB1		PBLs	PBLs + EGb	EGb effect	PBLs + VSV	PBLs + VSV + EGb	EGB effect
AD	Median	2.99	1.63	−0.74	3.87	1.77	−0.68
AD	CI95	1.41; 7.73	0.55; 4.45	−1.72; 0.46	0.78; 15.27	0.79; 6.55	−1.93; 0.69
Control	Median	2.09	0.87	−0.76	1.88	1.75	−0.18
Control	CI95	0.99; 4.11	0.45; 1.72	−1.54; −0.14	1.14; 3.26	0.78; 3.82	−0.83; 0.62
AD vs. Control	delta	0.88	0.94	−0.01	5.12	0.5	−0.55
	CI95	−1.87; 7.59	−0.62; 4.33	−1.25; 1.56	−1.06; 21.44	−3.2; 11.06	−2.02; 1.13
	p-value	p = 0.9873			p = 0.4645
NFkp65		PBLs	PBLs + EGb	EGb effect	PBLs + VSV	PBLs + VSV + EGb	EGB effect
AD	Median	2.63	2.5	−0.16	4.71	2.9	−0.39
AD	CI95	1.16; 6.81	0.92; 6.18	−1.05; 0.89	0.98; 16.35	1.38; 10.06	−1.56; 1.1
Control	Median	1.93	0.99	−0.63	2.06	2.46	0.1
Control	CI95	0.88; 4.11	0.56; 1.75	−1.36; 0.08	1.22; 3.46	1.01; 5.68	−0.6; 0.88
AD vs. Control	delta	0.77	1.9	0.42	5.28	0.79	−0.55
	CI95	−2.05; 6.57	−0.12; 5.4	−0.79; 1.84	−0.94; 20.13	−4.27; 17	−1.99; 1.17
	p-value	p = 0.5612			p = 0.4365
MxA		PBLs	PBLs + EGb	EGb effect	PBLs + VSV	PBLs + VSV + EGb	EGB effect
AD	Median	0.47	0.2	−0.98	21.82	0.22	−4.49
AD	CI95	0.17; 1.32	0.07; 0.37	−1.77; −0.12	6.87; 64.67	0.1; 0.62	−5.81; −3.17
Control	Median	1.32	0.15	−2.13	21.69	1.07	−3.01
Control	CI95	0.27; 6.13	0.07; 0.32	−3.78; −0.46	14.08; 33.2	0.34; 3.57	−4.1; −2.12
AD vs. Control	delta	−2.23	0.02	1.19	6.3	−1.54	−1.5
	CI95	−8.97; 0.34	−0.42; 0.44	−1.14; 3.17	−17.07; 73.42	−3.86; 0.03	−3.15; 0.07
	p-value	p = 0.3098			p = 0.069