Table 1.
The results of the studies that evaluated serum IMA levels in skin disorders.
| Disease | Study Participants | IMA [Patients vs. Controls] | Conclusion | Reference |
|---|---|---|---|---|
| Psoriasis | 26 patients 26 healthy subjects |
Higher | Elevated levels of IMA could represent a mechanism of adaptation to chronic hypoxia and oxidative stress that are present in psoriasis. | Ozdemir et al. (2012) [30] |
| Psoriasis | 43 patients 43 healthy subjects |
Higher | IMA is a marker of oxidative stress and chronic inflammation in psoriasis. | Chandrashekar et al. (2015) [31] |
| Psoriasis | 45 patients 44 healthy subjects |
Higher | IMA can be considered a useful marker for the evaluation of oxidative stress in patients with psoriasis, especially those with a long duration of disease. | Isik et al. (2016) [32] |
| Psoriasis | 44 patients 43 healthy subjects |
Higher | In psoriasis, there are elevated levels of IMA in association with chronic inflammation. | Pektas et al. (2018) [33] |
| Psoriasis | 87 patients 60 healthy subjects |
Higher | High levels of IMA indicate elevated levels of oxidative stress in psoriasis. | Kirmit et al. (2020) [34] |
| Acne vulgaris | 74 patients 60 healthy subjects |
Higher | IMA is a marker of oxidative stress in patients with acne vulgaris. | Gurel et al. (2019) [35] |
| Acne vulgaris | 90 patients 30 healthy subjects |
Higher | In patients with acne vulgaris, pathological processes such as hypoxia and ischemia can be assessed by measuring the levels of IMA and methylarginine. | Akyurek et al. (2020) [8] |
| Acne vulgaris | 30 patients 18 healthy subjects |
Higher | Serum IMA level could be considered an independent predictor of acne vulgaris susceptibility and activity. | Ebrahim et al. (2020) [36] |
| Hidradenitis suppurativa | 40 patients 40 healthy subjects |
No significant difference | There was a significant difference in IMA levels between patients with metabolic syndrome and those without metabolic syndrome, but not between patients and controls. | Akdogan et al. (2018) [37] |
| Hidradenitis suppurativa | 30 patients 30 healthy subjects |
Higher | Oxidative stress is involved in the pathogenesis of hidradenitis suppurativa. | Balik et al. (2022) [38] |
| Vitiligo | 60 patients 60 healthy subjects |
Higher | IMA is an independent predictor of oxidative stress in patients with vitiligo. | Atas et al. (2017) [39] |
| Acute urticaria | 37 patients 40 healthy subjects |
Higher | IMA could be a marker of oxidative stress in acute urticaria. | Otal et al. (2021) [40] |
| Chronic urticaria | 30 patients 20 healthy subjects |
Higher | Oxidative stress may be involved in the pathogenesis of chronic urticaria. | Akdag et al. (2020) [41] |
| Behcet’s disease | 28 patients 27 healthy subjects |
Higher | Increased levels of IMA are the result of the inflammatory response induced by oxidative stress. | Ozyazgan et al. (2013) [42] |
| Behcet’s disease | 26 patients 28 healthy subjects |
No significant diference | IMA may represent a marker of disease complications in patiens with active disease. | Kilic et al. (2016) [43] |
| Behcet’s disease | 93 patients 62 healthy subjects |
Higher | IMA may be considered a biomarker in Bekcet’s disease. | Omma et al. (2018) [44] |
| Behcet’s disease | 48 patients 38 healthy subjects |
Higher | IMA is a marker of oxidative stress and disease activity in patients with Behcet’s disease. | Fouad et al. (2019) [45] |
| Bechcet’s disease | 57 patients 45 healthy subjects |
Higher | IMA is a more reliable marker to assess oxidative stress than total oxidant status, total antioxidant capacity and oxidative stress index. | Keskin et al. (2019) [46] |
| Behcet’s disease | 39 patients 40 healthy subjects |
Higher | IMA may be used as a marker of oxidative stress in patients with Behcet’s disease. | Kor et al. (2022) [47] |
IMA—Ischemia-modified albumin.