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HPLC-IMER-MS bioanalytical device. Immobilized AChE ((
) continuously converts ACh (
) into Cho (
) when no AChE inhibitors are eluted from the HPLC column (Equation (1)); when AChE inhibitors (
) are present in the eluate, they bind to the immobilized AChE, resulting in an increase in remaining ACh and a decrease in detected Cho (Equation (2)). Reprinted with permission from Ref. [25]. Copyright 2017 Elsevier.
