Table 2.
Characteristics Analyzed | Results |
---|---|
Molecular weight | 478 g/mol |
Log P | 7.91 |
Solubility in PBS, pH 7.4 | 11.54 ± 1.53 µg/mL |
Solubility in SGF | 7.39 ± 0.26 µg/mL |
Solubility in ISF | 10.19 ± 0.12 µg/mL |
A–B permeability (Caco-2, pH 6.5/7.4) | 1.0 ± 0.14 10−6 cm/s |
B–A permeability (Caco-2, pH 6.5/7.4) | 0.7 ± 0.05 10−6 cm/s |
Stability on human microsomes | T1/2: 10 min |