Table 7.
Physical–chemical parameters of β-caryophyllene compared to commercial anti-inflammatories drugs (diclofenac, ibuprofen, and naproxen). a Molecular weight (Da); b Partition coefficient in a logarithmic scale; c Native water solubility (mg/mL); d Number of hydrogen bond acceptor (HBA); e Number of hydrogen bond donor (HBD); f Number of Lipinski’s rules broken (NLRB).
| Compounds | Physical–Chemical Properties | |||||
|---|---|---|---|---|---|---|
| MW a | LogP b | S + WS c | HBA d | HBD e | NLRB f | |
| β-cariophyllene | 204 | 4.6 | 0.002 | 0 | 0 | 0 |
| diclofenac | 295 | 3.89 | 0.0464 | 3 | 2 | 0 |
| Ibuprofen | 206 | 3.0 | 0.1 | 2 | 1 | 0 |
| Naproxen | 230 | 2.69 | 0.0649 | 3 | 1 | 0 |